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3Medicinal

Alpha-GPC

Also sold as L-alpha glycerylphosphorylcholine, choline alfoscerate

A choline source used as a nootropic and for power output — some supporting data, and one large observational study linked it to higher stroke risk.

TrustedSupp Tier System™ · Tier 3Take as a defined course

Evidence strength

38/100Limited
WEAKLIMITEDMODERATESTRONGVERY STRONG

What the evidence supports: cognition in older dementia trials and modest power output in athletes.

This scores how well-supported the claim above is — not how much benefit you personally would get. A high score on a narrow claim does not extend to everything the product is marketed for.

How long to take it

Course-based rather than indefinite, given the unresolved long-term question.

Who it's actually for

People exploring cognitive or power-output support; think twice if you have cardiovascular risk factors.

Safe upper limit

Unverified
No formal upper limit; 300–1,200 mg daily in studies
Short-term use is usually well tolerated. A large observational study reported a higher stroke risk among long-term users. That doesn't prove cause, but it's a reason for caution with long-term use, especially with vascular risk factors.
No source or citation attached yet.

Interactions to know about

No commonly documented medication clashes in our data. That is not the same as none existing.

Other supplements:

Run your full list through the interaction check.

Practical notes

  • The stroke association is observational — a signal, not proof.
  • Counts toward total choline intake.
  • Citicoline is an alternative choline source with its own evidence base.