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3Medicinal

Evening primrose oil

Also sold as EPO, GLA, gamma-linolenic acid

Used for breast tenderness and eczema with mixed results.

3TrustedSupp Tier System™ · Tier 3Take as a defined course
Check before you startThis one has documented interactions with medication classes where the consequences are serious. If you take any prescription medicine, run it past a pharmacist before starting.

How long to take it

Three months to judge effect.

Who it's actually for

Cyclical breast tenderness, with modest expectations.

Safe upper limit

Unverified
No formal limit; 1–3 g daily is typical
Mild antiplatelet effect. May lower seizure threshold.
No source attached yet. Treat this as a starting point, not a citation, until reviewed.

Interactions to know about

  • Blood thinners / antiplateletsWarfarin, apixaban, rivaroxaban, clopidogrel, aspirin
  • Anti-seizure medicationPhenytoin, valproate, carbamazepine, lamotrigine
  • AntipsychoticsRisperidone, olanzapine, quetiapine

Other supplements:

Run your full list through the interaction check.

Practical notes

  • Systematic reviews have not supported the eczema claims.
  • Avoid with epilepsy and stop before surgery.