Check before you startThis one has documented interactions with medication classes where the consequences are serious. If you take any prescription medicine, run it past a pharmacist before starting.
How long to take it
Short courses at most, and not if you drink regularly.
Who it's actually for
Anxiety, with genuine caution and ideally medical oversight.
Safe upper limit
UnverifiedRestricted or banned in several countries; 250 mg kavalactones daily is a common cap
Documented cases of severe liver failure, some requiring transplant. Risk rises with alcohol and other liver-processed drugs.
No source attached yet. Treat this as a starting point, not a citation, until reviewed.
Interactions to know about
- Sedatives / sleep medication — Benzodiazepines, zopiclone, zolpidem, opioids
- Liver disease or impairment — Hepatitis, cirrhosis, fatty liver
- Antidepressants — SSRIs, SNRIs, MAOIs, tricyclics
Other supplements:
Run your full list through the interaction check.
Practical notes
- Do not combine with alcohol.
- Avoid entirely with any liver condition.
- Check whether it is even legal where you live.