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3Medicinal

Lemon balm

Also sold as Melissa officinalis

Gentle traditional calmative, often combined with valerian.

3TrustedSupp Tier System™ · Tier 3Take as a defined course
Check before you startThis one has documented interactions with medication classes where the consequences are serious. If you take any prescription medicine, run it past a pharmacist before starting.

How long to take it

Short courses.

Who it's actually for

Mild situational anxiety or difficulty settling.

Safe upper limit

Unverified
No formal limit; 300–600 mg extract
Mild sedation, additive with other sedatives. May affect thyroid function at high doses.
No source attached yet. Treat this as a starting point, not a citation, until reviewed.

Interactions to know about

  • Sedatives / sleep medicationBenzodiazepines, zopiclone, zolpidem, opioids
  • Thyroid medicationLevothyroxine, carbimazole, methimazole

Other supplements:

Run your full list through the interaction check.

Practical notes

  • Commonly paired with valerian in sleep formulas.
  • Avoid with thyroid medication without discussing it first.