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3Medicinal

Lion's mane

Also sold as Hericium erinaceus

Studied for nerve growth factor and cognition; evidence is still early.

3TrustedSupp Tier System™ · Tier 3Take as a defined course
Check before you startThis one has documented interactions with medication classes where the consequences are serious. If you take any prescription medicine, run it past a pharmacist before starting.

How long to take it

Twelve to sixteen weeks in the available trials.

Who it's actually for

People exploring cognitive support, with realistic expectations.

Safe upper limit

Unverified
No formal limit; 500–3,000 mg daily in trials
Generally well tolerated. Allergic reactions reported, including skin and respiratory.
No source attached yet. Treat this as a starting point, not a citation, until reviewed.

Interactions to know about

  • Blood thinners / antiplateletsWarfarin, apixaban, rivaroxaban, clopidogrel, aspirin
  • Diabetes medicationMetformin, insulin, gliclazide, SGLT2 inhibitors

Other supplements:

Run your full list through the interaction check.

Practical notes

  • Fruiting body and mycelium products differ substantially — check which you're buying.
  • Human trials are few and small.