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3Medicinal

Pycnogenol

Also sold as French maritime pine bark extract, pine bark extract

A branded pine bark extract studied for circulation and venous insufficiency — the evidence is mostly small and manufacturer-linked.

TrustedSupp Tier System™ · Tier 3Take as a defined course
Check before you startThis one has documented interactions with medication classes where the consequences are serious. If you take any prescription medicine, run it past a pharmacist before starting.

Evidence strength

38/100Limited
WEAKLIMITEDMODERATESTRONGVERY STRONG

What the evidence supports: venous insufficiency symptoms in small, largely industry-linked trials.

This scores how well-supported the claim above is — not how much benefit you personally would get. A high score on a narrow claim does not extend to everything the product is marketed for.

How long to take it

Course-based, typically 8–12 weeks.

Who it's actually for

People with chronic venous insufficiency symptoms, with modest expectations.

Safe upper limit

Unverified
No formal upper limit; 100–200 mg daily in most trials
Generally well tolerated. It may stimulate the immune system and has mild blood-thinning effects.
No source or citation attached yet.

Interactions to know about

Run your full list through the interaction check.

Practical notes

  • Most studies are small and industry-connected.
  • May add to anticoagulant effects — stop before surgery.
  • Avoid with autoimmune disease or immunosuppressants unless your doctor agrees.