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3Medicinal

Reishi

Also sold as Ganoderma lucidum

Used for sleep and immune modulation; may increase bleeding risk.

3TrustedSupp Tier System™ · Tier 3Take as a defined course
Check before you startThis one has documented interactions with medication classes where the consequences are serious. If you take any prescription medicine, run it past a pharmacist before starting.

How long to take it

Course-based. Long continuous use is not well studied.

Who it's actually for

People exploring sleep or immune support.

Safe upper limit

Unverified
No formal limit; 1.5–9 g dried mushroom equivalent
Antiplatelet effect. Rare liver injury has been reported with powdered forms.
No source attached yet. Treat this as a starting point, not a citation, until reviewed.

Interactions to know about

  • Blood thinners / antiplateletsWarfarin, apixaban, rivaroxaban, clopidogrel, aspirin
  • ImmunosuppressantsCiclosporin, tacrolimus, azathioprine, biologics, steroids
  • Blood pressure medicationBeta blockers, calcium channel blockers, ACE inhibitors
  • Liver disease or impairmentHepatitis, cirrhosis, fatty liver

Other supplements:

Run your full list through the interaction check.

Practical notes

  • Stop before surgery.
  • Avoid with autoimmune disease or immunosuppressants.