Check before you startThis one has documented interactions with medication classes where the consequences are serious. If you take any prescription medicine, run it past a pharmacist before starting.
How long to take it
Course-based, under medical supervision if you have any mood diagnosis.
Who it's actually for
Osteoarthritis and low mood — but not alongside psychiatric medication without oversight.
Safe upper limit
UnverifiedNo formal limit; 400–1,600 mg daily in trials
Serotonergic. Combined with antidepressants it risks serotonin syndrome, and it can precipitate mania in bipolar disorder.
No source attached yet. Treat this as a starting point, not a citation, until reviewed.
Interactions to know about
- Antidepressants — SSRIs, SNRIs, MAOIs, tricyclics
- Tramadol — Serotonergic painkiller
- Triptans — Sumatriptan and similar migraine drugs
- Parkinson's medication — Levodopa / carbidopa
Other supplements:
Run your full list through the interaction check.
Practical notes
- Never combine with SSRIs, SNRIs, tramadol, or St John's wort.
- Can trigger mania — avoid in bipolar disorder unless a psychiatrist agrees.
- Take on an empty stomach; enteric-coated tablets absorb better.