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Vitamin B3 (Niacin)

Also sold as Niacin, nicotinamide, nicotinic acid

Deficiency is rare. High-dose niacin acts as a lipid drug, not a supplement.

2TrustedSupp Tier System™ · Tier 2Take until levels correct

How long to take it

Only under medical supervision at therapeutic doses.

Who it's actually for

Prescribed for specific lipid disorders. Not a self-directed supplement at high doses.

Safe upper limit

Unverified
35 mg per day supplemental nicotinic acid
Above this, flushing is common and liver injury is a genuine risk — especially with slow-release forms.
No source attached yet. Treat this as a starting point, not a citation, until reviewed.

Interactions to know about

  • Statins — Atorvastatin, simvastatin, rosuvastatin
  • Diabetes medication — Metformin, insulin, gliclazide, SGLT2 inhibitors

Other supplements:

Run your full list through the interaction check.

Practical notes

  • Slow-release niacin is the form most associated with liver toxicity.
  • Nicotinamide does not cause flushing and does not lower cholesterol.